Adeno associated virus (
AAV) is a kind of single strand DNA defective virus with simple structure and no envelope. It has the ability to infect divided or non divided cells, can meet the packaging of larger genes, is the preferred tool for overexpressing genes, and has the characteristics of good safety, wide host cell range, low epidemic resistance, and long time to express foreign genes in vivo.
Cell Valley provides adeno-associated virus vectors with different specifications and full serotypes. It includes four subtypes: single gene, single promoter double gene (IRES), double promoter double gene and double promoter double gene (WPRE).
The advantages of this series of products include:
① high safety and low pathogenicity to human;
② It is infectious to both mitotic and non - mitotic cells;
③ It can effectively proliferate;
④ The virus titer is high.
Adeno associated virus (
AAV) is a member of the parvoviridae family. It is a kind of icosahedral parvovirus that can not replicate independently and has no envelope. Its diameter is about 20-26nm, and it contains 4.7kb linear single strand DNA as its genome. The recombinant adeno-associated virus (r
AAV) used in the study is a gene vector modified from the non pathogenic wild type
AAV. Because of its variety, low immunogenicity, high safety, wide host cell range (infectious to both schizoid and non schizoid cells), strong diffusion ability, and long time to express genes in vivo, R
AAV is regarded as one of the most promising vectors for gene research and gene therapy.